Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine.

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Title: Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine.
Authors: Liu J; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gang S; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kikawa C; Division of Basic Sciences and Computational Biology Program, Fred Hutch Cancer Center, Seattle, WA.; Department of Genome Sciences, University of Washington, Seattle, WA., Rodriguez AJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA., Li SH; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ye N; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Griffiths T; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Drapeau EM; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Atkinson RK; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Loes AN; Division of Basic Sciences and Computational Biology Program, Fred Hutch Cancer Center, Seattle, WA., Collman RG; Division of Basic Sciences and Computational Biology Program, Fred Hutch Cancer Center, Seattle, WA., Ferguson JA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA., Bloom JD; Division of Basic Sciences and Computational Biology Program, Fred Hutch Cancer Center, Seattle, WA.; Howard Hughes Medical Institute, Seattle, WA., Hensley SE; Department of Microbiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 22. Date of Electronic Publication: 2026 Feb 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.64898/2026.02.20.26346746