PLCG1 promotes sevoflurane-induced neuronal ferroptosis by enhancing K63-linked ubiquitination and proteasomal degradation of LAMP2A.

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Title: PLCG1 promotes sevoflurane-induced neuronal ferroptosis by enhancing K63-linked ubiquitination and proteasomal degradation of LAMP2A.
Authors: Chen J; Department of Anesthesiology, Anhui Provincial Children's Hospital (Anhui Provincial Women and Children's Center), No. 39 Wangjiang East Road, Hefei City, 230000, Anhui Province, China., Cai Y; Department of Anesthesiology, Anhui Provincial Children's Hospital (Anhui Provincial Women and Children's Center), No. 39 Wangjiang East Road, Hefei City, 230000, Anhui Province, China., Wang J; Department of Anesthesiology, Anhui Provincial Children's Hospital (Anhui Provincial Women and Children's Center), No. 39 Wangjiang East Road, Hefei City, 230000, Anhui Province, China., Yue K; Department of Anesthesiology, Anhui Provincial Children's Hospital (Anhui Provincial Women and Children's Center), No. 39 Wangjiang East Road, Hefei City, 230000, Anhui Province, China., Sun Y; Department of Anesthesiology, Anhui Provincial Children's Hospital (Anhui Provincial Women and Children's Center), No. 39 Wangjiang East Road, Hefei City, 230000, Anhui Province, China. sunyy168@126.com.
Source: Experimental brain research [Exp Brain Res] 2026 Feb 27; Vol. 244 (4). Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0043312 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1106 (Electronic) Linking ISSN: 00144819 NLM ISO Abbreviation: Exp Brain Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1106
DOI:10.1007/s00221-026-07233-w