Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.

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Title: Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.
Authors: Zhu B; Department of Chemistry, Texas A&M University, College Station, Texas, USA., Pidugu LS; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Cook ME; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Nie XY; Department of Biology, Center For Biological Clock Research, Texas A&M University, College Station, Texas, USA., Amarasekara EAPT; Department of Chemistry, Texas A&M University, College Station, Texas, USA., Menet JS; Department of Biology, Center For Biological Clock Research, Texas A&M University, College Station, Texas, USA., Drohat AC; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sczepanski JT; Department of Chemistry, Texas A&M University, College Station, Texas, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA. Electronic address: jon.sczepanski@chem.tamu.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Apr; Vol. 302 (4), pp. 111308. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Department of Chemistry, Texas A&M University, College Station, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Pidugu+LS%22">Pidugu LS</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cook+ME%22">Cook ME</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nie+XY%22">Nie XY</searchLink>; Department of Biology, Center For Biological Clock Research, Texas A&M University, College Station, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Amarasekara+EAPT%22">Amarasekara EAPT</searchLink>; Department of Chemistry, Texas A&M University, College Station, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Menet+JS%22">Menet JS</searchLink>; Department of Biology, Center For Biological Clock Research, Texas A&M University, College Station, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Drohat+AC%22">Drohat AC</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sczepanski+JT%22">Sczepanski JT</searchLink>; Department of Chemistry, Texas A&M University, College Station, Texas, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA. Electronic address: jon.sczepanski@chem.tamu.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Apr; Vol. 302 (4), pp. 111308. <i>Date of Electronic Publication: </i>2026 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2026.111308
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        Text: English
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        StartPage: 111308
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      – TitleFull: Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids.
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              Text: 2026 Apr
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              Y: 2026
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