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STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.

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Title: STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.
Authors: Huang C; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Babu VS; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bammidi S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arnold JN; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Ebeling M; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Widmer G; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Strassburger P; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Lazendic M; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Grüner S; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Koester J; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Dutta P; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hose S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Singh S; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA., Gautam P; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lad EM; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA., Westenskow PD; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Kutsyr O; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Csaky KG; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA., Ghosh S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sripathi SR; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.; Department of Ophthalmology, University of Texas Southwestern Medical Center, Texas, Dallas, USA., Proia AD; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC, USA., Flores-Bellver M; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Sinha D; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@jhmi.edu., Feenstra D; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. derrick.feenstra@roche.com.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 27; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Babu+VS%22">Babu VS</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bammidi+S%22">Bammidi S</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+JN%22">Arnold JN</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ebeling+M%22">Ebeling M</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Widmer+G%22">Widmer G</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Strassburger+P%22">Strassburger P</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lazendic+M%22">Lazendic M</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grüner+S%22">Grüner S</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Koester+J%22">Koester J</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dutta+P%22">Dutta P</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hose+S%22">Hose S</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gautam+P%22">Gautam P</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lad+EM%22">Lad EM</searchLink>; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Westenskow+PD%22">Westenskow PD</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kutsyr+O%22">Kutsyr O</searchLink>; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Csaky+KG%22">Csaky KG</searchLink>; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sripathi+SR%22">Sripathi SR</searchLink>; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.; Department of Ophthalmology, University of Texas Southwestern Medical Center, Texas, Dallas, USA.<br /><searchLink fieldCode="AU" term="%22Proia+AD%22">Proia AD</searchLink>; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Bellver+M%22">Flores-Bellver M</searchLink>; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+D%22">Sinha D</searchLink>; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@jhmi.edu.<br /><searchLink fieldCode="AU" term="%22Feenstra+D%22">Feenstra D</searchLink>; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. derrick.feenstra@roche.com.
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