STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration.
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| Title: | STING activation induces polarized cytokine secretion of IFN-β and IL-17A promoting photoreceptor death and choroidal disruption in age-related macular degeneration. |
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| Authors: | Huang C; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Babu VS; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bammidi S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arnold JN; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Ebeling M; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Widmer G; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Strassburger P; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Lazendic M; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Grüner S; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Koester J; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Dutta P; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hose S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Singh S; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA., Gautam P; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lad EM; Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA., Westenskow PD; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Kutsyr O; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Csaky KG; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA., Ghosh S; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sripathi SR; Henderson Ocular Stem Cell Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.; Department of Ophthalmology, University of Texas Southwestern Medical Center, Texas, Dallas, USA., Proia AD; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC, USA., Flores-Bellver M; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Sinha D; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@jhmi.edu., Feenstra D; Roche Pharma Research and Early Development, Ophthalmology Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. derrick.feenstra@roche.com. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 27; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08491-w |
