A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation.

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Title: A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation.
Authors: Bai YP; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Yin Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China., Wang SM; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Chen JM; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China., Zhang ZH; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Zhu ZQ; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China., Shao GX; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Zhu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Jiang YY; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. yyjiang@ustc.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn., Sun BC; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. sunbc@ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn., Xu DQ; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul; Vol. 47 (7), pp. 1840-1855. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01745-x