Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia.
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| Title: | Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia. |
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| Authors: | Hurley T; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland., Quirke F; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; School of Medicine, University of Limerick, Limerick, Ireland., Branagan A; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Department of Paediatrics, The Coombe Hospital, Dublin, Ireland., McCarthy R; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland., Finucane E; Evidence Synthesis Ireland, University of Galway, Galway, Ireland., King G; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Taneri PE; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland, University of Galway, Galway, Ireland.; Cochrane Ireland, University of Galway, Galway, Ireland., El-Dib M; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bloomfield FH; Liggins Institute, University of Auckland, Auckland, New Zealand., Maeso B; James Lind Alliance, School of Healthcare Enterprise and Innovation, University of Southampton, Southampton, UK., Pilon B; Hope for HIE, West Bloomfield, MI, USA., Bonifacio S; Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA., Wusthoff CJ; Department of Neurology, University of California- Davis, Sacramento, CA, USA., Chalak L; Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Bearer CF; Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Murray DM; INFANT Research Centre, Cork, Ireland; Department of Pediatrics and Child Health, University College Cork, Cork, Ireland., Badawi N; Cerebral Palsy Alliance Research Institute, Specialty of Child & Adolescent Health, Sydney Medical School, Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.; Grace Centre for Newborn Intensive Care, Sydney Children's Hospital Network, The University of Sydney, Westmead, NSW, Australia., Campbell SK; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA., Mulkey SB; Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, VA, USA.; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington DC, VA, USA.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington DC, VA, USA., Gressens P; Université Paris Cité, NeuroDiderot, Inserm, Paris, France., Ferriero DM; Department of Pediatrics and Neurology, University of California San Francisco, Weill Institute for Neurosciences, San Francisco, CA, USA., Vries LS; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands., Walker K; Department of Newborn Care, Royal Prince Alfred Hospital, Sydney, Local Health District, Sydney, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Kay S; PEEPS-HIE, Manchester, UK., Boylan GB; INFANT Research Centre, Cork, Ireland; Department of Pediatrics and Child Health, University College Cork, Cork, Ireland., Gale C; Neonatal Medicine, School of Public Health, Faculty of Medicine, Chelsea and Westminster Campus, Centre for Paediatrics and Child Health, Imperial College London, London, UK., Robertson NJ; Institute for Women's Health, University College London, London, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., D'Alton M; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA., Nesterenko TH; Department of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA., Mietzsch U; Division of Neonatology, Department of Pediatrics, University of Washington Medical School, Seattle Children's Hospital, Seattle, WA, USA., Gunn AJ; Departments of Physiology and Paediatrics, School of Medical Sciences, University of Auckland, Auckland, New Zealand., Nelson KB; National Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA., Devane D; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland, University of Galway, Galway, Ireland.; Cochrane Ireland, University of Galway, Galway, Ireland., Molloy EJ; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland. Eleanor.molloy@tcd.ie.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland. Eleanor.molloy@tcd.ie.; Department of Paediatrics, The Coombe Hospital, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Department of Neonatology, Children's Hospital Ireland at Crumlin and Tallaght, Dublin, Ireland. Eleanor.molloy@tcd.ie. |
| Corporate Authors: | Steering Group for DEFiNE (Definition of Neonatal Encephalopathy) |
| Source: | Pediatric research [Pediatr Res] 2026 Feb 27. Date of Electronic Publication: 2026 Feb 27. |
| Publication Type: | Journal Article; Systematic Review |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41760908 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hurley+T%22">Hurley T</searchLink>; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Quirke+F%22">Quirke F</searchLink>; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; School of Medicine, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Branagan+A%22">Branagan A</searchLink>; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Department of Paediatrics, The Coombe Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22McCarthy+R%22">McCarthy R</searchLink>; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.<br /><searchLink fieldCode="AU" term="%22Finucane+E%22">Finucane E</searchLink>; Evidence Synthesis Ireland, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22King+G%22">King G</searchLink>; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Taneri+PE%22">Taneri PE</searchLink>; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland, University of Galway, Galway, Ireland.; Cochrane Ireland, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22El-Dib+M%22">El-Dib M</searchLink>; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bloomfield+FH%22">Bloomfield FH</searchLink>; Liggins Institute, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Maeso+B%22">Maeso B</searchLink>; James Lind Alliance, School of Healthcare Enterprise and Innovation, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Pilon+B%22">Pilon B</searchLink>; Hope for HIE, West Bloomfield, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bonifacio+S%22">Bonifacio S</searchLink>; Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wusthoff+CJ%22">Wusthoff CJ</searchLink>; Department of Neurology, University of California- Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chalak+L%22">Chalak L</searchLink>; Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bearer+CF%22">Bearer CF</searchLink>; Division of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Murray+DM%22">Murray DM</searchLink>; INFANT Research Centre, Cork, Ireland; Department of Pediatrics and Child Health, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Badawi+N%22">Badawi N</searchLink>; Cerebral Palsy Alliance Research Institute, Specialty of Child & Adolescent Health, Sydney Medical School, Faculty of Medicine & Health, The University of Sydney, Sydney, NSW, Australia.; Grace Centre for Newborn Intensive Care, Sydney Children's Hospital Network, The University of Sydney, Westmead, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Campbell+SK%22">Campbell SK</searchLink>; Department of Physical Therapy, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mulkey+SB%22">Mulkey SB</searchLink>; Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, VA, USA.; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington DC, VA, USA.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington DC, VA, USA.<br /><searchLink fieldCode="AU" term="%22Gressens+P%22">Gressens P</searchLink>; Université Paris Cité, NeuroDiderot, Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ferriero+DM%22">Ferriero DM</searchLink>; Department of Pediatrics and Neurology, University of California San Francisco, Weill Institute for Neurosciences, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vries+LS%22">Vries LS</searchLink>; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Walker+K%22">Walker K</searchLink>; Department of Newborn Care, Royal Prince Alfred Hospital, Sydney, Local Health District, Sydney, NSW, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kay+S%22">Kay S</searchLink>; PEEPS-HIE, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Boylan+GB%22">Boylan GB</searchLink>; INFANT Research Centre, Cork, Ireland; Department of Pediatrics and Child Health, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Gale+C%22">Gale C</searchLink>; Neonatal Medicine, School of Public Health, Faculty of Medicine, Chelsea and Westminster Campus, Centre for Paediatrics and Child Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Robertson+NJ%22">Robertson NJ</searchLink>; Institute for Women's Health, University College London, London, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22D'Alton+M%22">D'Alton M</searchLink>; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nesterenko+TH%22">Nesterenko TH</searchLink>; Department of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Mietzsch+U%22">Mietzsch U</searchLink>; Division of Neonatology, Department of Pediatrics, University of Washington Medical School, Seattle Children's Hospital, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gunn+AJ%22">Gunn AJ</searchLink>; Departments of Physiology and Paediatrics, School of Medical Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Nelson+KB%22">Nelson KB</searchLink>; National Institutes of Health, National Institute of Neurological Diseases and Stroke, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Devane+D%22">Devane D</searchLink>; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland.; Health Research Board - Trials Methodology Research Network (HRB-TMRN), University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland, University of Galway, Galway, Ireland.; Cochrane Ireland, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Molloy+EJ%22">Molloy EJ</searchLink>; Department of Pediatrics, School of Medicine, Trinity College Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Trinity Research in Childhood Centre (TRiCC), Centre, Ireland. Eleanor.molloy@tcd.ie.; Health Research Board Neonatal Encephalopathy PhD Training Network (NEPTuNE), Dublin, Ireland. Eleanor.molloy@tcd.ie.; Department of Paediatrics, The Coombe Hospital, Dublin, Ireland. Eleanor.molloy@tcd.ie.; Department of Neonatology, Children's Hospital Ireland at Crumlin and Tallaght, Dublin, Ireland. Eleanor.molloy@tcd.ie. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Steering+Group+for+DEFiNE+%28Definition+of+Neonatal+Encephalopathy%29%22">Steering Group for DEFiNE (Definition of Neonatal Encephalopathy)</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220100714%22">Pediatric research</searchLink> [Pediatr Res] 2026 Feb 27. <i>Date of Electronic Publication: </i>2026 Feb 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Systematic Review – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0100714 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1530-0447 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200313998%22">00313998 </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41760908 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41390-025-04750-2 Languages: – Code: eng Text: English Titles: – TitleFull: Systematic review of terminology, definitions, and eligibility criteria in trials of neonatal encephalopathy, hypoxic-ischemic encephalopathy, and perinatal asphyxia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hurley T – PersonEntity: Name: NameFull: Quirke F – PersonEntity: Name: NameFull: Branagan A – PersonEntity: Name: NameFull: McCarthy R – PersonEntity: Name: NameFull: Finucane E – PersonEntity: Name: NameFull: King G – PersonEntity: Name: NameFull: Taneri PE – PersonEntity: Name: NameFull: El-Dib M – PersonEntity: Name: NameFull: Bloomfield FH – PersonEntity: Name: NameFull: Maeso B – PersonEntity: Name: NameFull: Pilon B – PersonEntity: Name: NameFull: Bonifacio S – PersonEntity: Name: NameFull: Wusthoff CJ – PersonEntity: Name: NameFull: Chalak L – PersonEntity: Name: NameFull: Bearer CF – PersonEntity: Name: NameFull: Murray DM – PersonEntity: Name: NameFull: Badawi N – PersonEntity: Name: NameFull: Campbell SK – PersonEntity: Name: NameFull: Mulkey SB – PersonEntity: Name: NameFull: Gressens P – PersonEntity: Name: NameFull: Ferriero DM – PersonEntity: Name: NameFull: Vries LS – PersonEntity: Name: NameFull: Walker K – PersonEntity: Name: NameFull: Kay S – PersonEntity: Name: NameFull: Boylan GB – PersonEntity: Name: NameFull: Gale C – PersonEntity: Name: NameFull: Robertson NJ – PersonEntity: Name: NameFull: D'Alton M – PersonEntity: Name: NameFull: Nesterenko TH – PersonEntity: Name: NameFull: Mietzsch U – PersonEntity: Name: NameFull: Gunn AJ – PersonEntity: Name: NameFull: Nelson KB – PersonEntity: Name: NameFull: Devane D – PersonEntity: Name: NameFull: Molloy EJ IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 02 Text: 2026 Feb 27 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1530-0447 Titles: – TitleFull: Pediatric research Type: main |
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