Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial.

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Title: Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial.
Authors: Dipper A; Academic Respiratory Unit, University of Bristol, Bristol, UK., Sundaralingam A; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Imperial College Healthcare NHS Trust, London, UK. Electronic address: anand.sundaralingam@ndm.ox.ac.uk., Hedley E; Imperial College Healthcare NHS Trust, London, UK., Gudur S; Lancashire Teaching Hospitals, Preston, UK., Mills J; Lancashire Teaching Hospitals, Preston, UK., Sowden S; Lancashire Teaching Hospitals, Preston, UK., Corcoran JP; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK., Daneshvar C; Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospital Plymouth NHS Trust, Plymouth, UK., Craig C; Lung Cancer and Thoracic Surgery Directorate, Wythenshawe Hospital, Manchester NHS Foundation Trust, Manchester, UK., Moore AJ; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Milne A; Academic Respiratory Unit, University of Bristol, Bristol, UK., Clive A; North Bristol NHS Trust, Bristol, UK., Bhatnagar R; Academic Respiratory Unit, University of Bristol, Bristol, UK; North Bristol NHS Trust, Bristol, UK; Odense Respiratory Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Roberts ME; Sherwood Forest Hospitals NHS Trust, Sutton-in-Ashfield, UK., Nagarajan T; Macclesfield General Hospital, Macclesfield, UK., Kutubudin F; Macclesfield General Hospital, Macclesfield, UK., Wassal H; Macclesfield General Hospital, Macclesfield, UK., Aboushehata M; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Iftikhar S; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Haris M; University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK., Abraham M; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., Sudhir R; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., Panchal RK; National Institute for Health and Care Research, Leicester Biomedical Research Centre, Leicester, UK., de Fonseka D; Academic Respiratory Department, Sheffield Teaching Hospitals, Sheffield, UK., Bedawi EO; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Iqbal B; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK., Addala D; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK., Wrightson J; Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Menzies D; Glan Clwyd Hospital, Bodelwyddan, UK., Ratushnyak S; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK., Luengo-Fernandez R; National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK., Miller RF; Institute for Global Health, University College London, London, UK., White P; School of Data and Mathematics, University of the West of England, Bristol, UK., Munavvar M; Lancashire Teaching Hospitals, Preston, UK; School of Medicine, University of Central Lancashire, Preston, UK; Lancashire Teaching Hospitals, Preston, UK., Rahman NM; Oxford Respiratory Trials Unit, University of Oxford, Oxford, UK; Oxford National Institute for Health and Care Research Biomedical Research Centre, Oxford, UK., Maskell N; Academic Respiratory Unit, University of Bristol, Bristol, UK.
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Apr; Vol. 14 (4), pp. 341-349. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2619
DOI:10.1016/S2213-2600(25)00409-6