Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
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| Title: | Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A. |
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| Authors: | Chen J; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, The Affiliated LiHuili Hospital of Ningbo University, Ningbo, China., Xue M; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Mi S; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Fu A; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Chen W; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Sun Y; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Xia S; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Ge Q; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Luo J; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Yu Q; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Wang L; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. wangljzju@zju.edu.cn.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. wangljzju@zju.edu.cn., Chen S; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. chenshujie77@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. chenshujie77@zju.edu.cn.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. chenshujie77@zju.edu.cn. |
| Source: | Nature communications [Nat Commun] 2026 Mar 01; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-70220-w |
