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Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.

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Title: Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Authors: Chen J; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, The Affiliated LiHuili Hospital of Ningbo University, Ningbo, China., Xue M; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Mi S; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Fu A; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Chen W; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Sun Y; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Xia S; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Ge Q; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China., Luo J; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Yu Q; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Wang L; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. wangljzju@zju.edu.cn.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. wangljzju@zju.edu.cn., Chen S; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. chenshujie77@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. chenshujie77@zju.edu.cn.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. chenshujie77@zju.edu.cn.
Source: Nature communications [Nat Commun] 2026 Mar 01; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
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  Data: <searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.; Department of Gastroenterology, The Affiliated LiHuili Hospital of Ningbo University, Ningbo, China.<br /><searchLink fieldCode="AU" term="%22Xue+M%22">Xue M</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Mi+S%22">Mi S</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Fu+A%22">Fu A</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xia+S%22">Xia S</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ge+Q%22">Ge Q</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. wangljzju@zju.edu.cn.; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. wangljzju@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. wangljzju@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Institution of Gastroenterology, Zhejiang University, Hangzhou, China. chenshujie77@zju.edu.cn.; Prevention and Treatment Research Center for Senescent Disease, Zhejiang University School of Medicine, Hangzhou, China. chenshujie77@zju.edu.cn.; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. chenshujie77@zju.edu.cn.
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              Text: 2026 Mar 01
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