Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.

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Title: Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.
Authors: Lim SY; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Lee J; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Chang E; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Kwon JS; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Jang CY; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Seo Y; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Park JJ; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Na SH; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Park H; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Jang HM; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Yun SC; Department of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-C.Y.)., Kim SH; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).
Source: Annals of internal medicine [Ann Intern Med] 2026 Apr; Vol. 179 (4), pp. 478-485. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American College of Physicians--American Society of Internal Medicine Country of Publication: United States NLM ID: 0372351 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-3704 (Electronic) Linking ISSN: 00034819 NLM ISO Abbreviation: Ann Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1539-3704
DOI:10.7326/ANNALS-25-04883