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A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling.

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Title: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling.
Authors: Lin CT; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Chiou YS; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City, 80756, Taiwan., Yang JR; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704302, Taiwan., Wang JH; Department of Mathematics, National Chung Cheng University, Chiayi, 62102, Taiwan., Yen MC; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan., Li CR; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan. Electronic address: stone770116@gmail.com.
Source: Talanta [Talanta] 2026 Aug 01; Vol. 305, pp. 129582. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-3573
DOI:10.1016/j.talanta.2026.129582