A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling.
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| Title: | A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling. |
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| Authors: | Lin CT; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Chiou YS; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City, 80756, Taiwan., Yang JR; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704302, Taiwan., Wang JH; Department of Mathematics, National Chung Cheng University, Chiayi, 62102, Taiwan., Yen MC; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan., Li CR; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan. Electronic address: stone770116@gmail.com. |
| Source: | Talanta [Talanta] 2026 Aug 01; Vol. 305, pp. 129582. Date of Electronic Publication: 2026 Feb 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41775063 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lin+CT%22">Lin CT</searchLink>; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+YS%22">Chiou YS</searchLink>; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City, 80756, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+JR%22">Yang JR</searchLink>; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JH%22">Wang JH</searchLink>; Department of Mathematics, National Chung Cheng University, Chiayi, 62102, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+MC%22">Yen MC</searchLink>; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CR%22">Li CR</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Shih+CL%22">Shih CL</searchLink>; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan. Electronic address: stone770116@gmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222984816R%22">Talanta</searchLink> [Talanta] 2026 Aug 01; Vol. 305, pp. 129582. <i>Date of Electronic Publication: </i>2026 Feb 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>2984816R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3573 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200399140%22">00399140 </searchLink><i>NLM ISO Abbreviation: </i>Talanta <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41775063 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.talanta.2026.129582 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 129582 Titles: – TitleFull: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin CT – PersonEntity: Name: NameFull: Chiou YS – PersonEntity: Name: NameFull: Yang JR – PersonEntity: Name: NameFull: Wang JH – PersonEntity: Name: NameFull: Yen MC – PersonEntity: Name: NameFull: Li CR – PersonEntity: Name: NameFull: Shih CL IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1873-3573 Numbering: – Type: volume Value: 305 Titles: – TitleFull: Talanta Type: main |
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