A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling.
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| Title: | A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry-based drug metabolite profiling. |
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| Authors: | Lin CT; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Chiou YS; Master Degree Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City, 80756, Taiwan., Yang JR; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, 704302, Taiwan., Wang JH; Department of Mathematics, National Chung Cheng University, Chiayi, 62102, Taiwan., Yen MC; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, 80756, Taiwan., Li CR; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan., Shih CL; Clinical Research Center, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, 60002, Taiwan. Electronic address: stone770116@gmail.com. |
| Source: | Talanta [Talanta] 2026 Aug 01; Vol. 305, pp. 129582. Date of Electronic Publication: 2026 Feb 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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