Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.

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Title: Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.
Authors: Muddineni SSNA; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Katz-Even C; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Zipin-Roitman A; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Rasoulouniriana D; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Singha Roy D; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Aborgies R; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel., Beider K; Hematology Division, Chaim Sheba Medical Center, Tel-Hashomer, Israel., Raz Y; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel.; Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel., Solomon N; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel.; Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel., Hershkovitz G; Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel., Shulman Y; Department of Obstetrics and Gynecology, Gynecologic Oncology Division, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel., Chen R; Helen Schneider Hospital for Women, Rabin Medical Center, Petach-Tikva, Israel., Weizman E; G-INCPM, Weizmann Institute of Science, Rehovot, Israel., Waskow C; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.; Institute of Biochemistry and Biophysics, Faculty of Biological Sciences, Friedrich-Schiller-University, Jena, Germany., Nagler A; Hematology Division, Chaim Sheba Medical Center, Tel-Hashomer, Israel., Milyavsky M; Department of Pathology, Tel Aviv University, Tel-Aviv, Israel. mmilyavsky@post.tau.ac.il.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel. mmilyavsky@post.tau.ac.il.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 03; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-026-08502-w