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Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.

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Title: Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.
Authors: Nirachonkul W; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand., Farrell MP; Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS, USA., Tolbert TJ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA., Okonogi S; Department of Pharmaceutical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand., Tima S; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand., Anuchapreeda S; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand., Chiampanichayakul S; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand., Siahaan TJ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2026 Dec; Vol. 41 (1), pp. 2638027. Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.
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  Data: <searchLink fieldCode="AU" term="%22Nirachonkul+W%22">Nirachonkul W</searchLink>; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.<br /><searchLink fieldCode="AU" term="%22Farrell+MP%22">Farrell MP</searchLink>; Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Tolbert+TJ%22">Tolbert TJ</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Okonogi+S%22">Okonogi S</searchLink>; Department of Pharmaceutical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.<br /><searchLink fieldCode="AU" term="%22Tima+S%22">Tima S</searchLink>; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand.<br /><searchLink fieldCode="AU" term="%22Anuchapreeda+S%22">Anuchapreeda S</searchLink>; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand.<br /><searchLink fieldCode="AU" term="%22Chiampanichayakul+S%22">Chiampanichayakul S</searchLink>; Department of Medical Technology, Chiang Mai University, Chiang Mai, Thailand.; Center of Excellence in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai, Thailand.; Cancer Research Unit of Associated Medical Sciences (AMS CRU), Chiang Mai University, Thailand.<br /><searchLink fieldCode="AU" term="%22Siahaan+TJ%22">Siahaan TJ</searchLink>; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2026 Dec; Vol. 41 (1), pp. 2638027. <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1080/14756366.2026.2638027
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      – Code: eng
        Text: English
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        StartPage: 2638027
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      – TitleFull: Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate.
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              M: 12
              Text: 2026 Dec
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              Y: 2026
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