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Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder.

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Title: Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder.
Authors: Siriratnam P; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom., Jokubaitis VG; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia., Van Der Walt A; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia., Sanfilippo PG; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia., Zhu C; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia., Etemadifar M; Department of Neurology, DrEtemadifar MS Institute, Isfahan University of Medical Sciences, Iran.; Faculty of Medicine, Isfahan University of Medical Sciences, Iran., Altintas A; Department of Neurology, School of Medicine and Koc University Research Center for Translational Medicine (KUTTAM), Koc University, School of Medicine, Istanbul, Turkey., Al-Asmi A; College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khodh, Oman., Laureys G; Department of Neurology, Universitary Hospital Ghent, Belgium., Meca-Lallana JE; Neurology Department, Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca), Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain., Foschi M; Department of Neuroscience, MS Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy., Alroughani R; Division of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait., Gomez-Figueroa E; Department for Neurology, Civil Hospital of Guadalajara Fray Antonio Alcalde, Mexico., Habek M; Department of Neurology, University Hospital Center Zagreb, Croatia.; University of Zagreb, School of Medicine, Zagreb, Croatia., Khoury SJ; Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Lebanon., Simo M; Department of Neurology, Semmelweis University, Budapest, Hungary., Singhal BSG; Bombay Hospital Institute of Medical Sciences, Mumbai, India., Jakob GB; Department of Neurology, University Medical Centre Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Slovenia., Fabis-Pedrini MJ; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Australia., Soysal A; Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey., Kermode AG; Perron Institute for Neurological and Translational Science, Sir Charles Gairdner Hospital, QEIIMC, University of Western Australia, Nedlands, Australia.; Personalised Medicine Centre, Health Futures Institute, Murdoch University, Australia., Shaygannejad V; Faculty of Medicine, Isfahan University of Medical Sciences, Iran., Kubala Havrdova E; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic., Millan-Pascual J; Neurology Department, Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca), Murcia, Spain.; NICEM Cathedra. UCAM-San Antonio Catholic University, Murcia, Spain., Roos I; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Victoria, Australia.; CORe, Department of Medicine, University of Melbourne, Victoria, Australia., Mccombe PA; Department of Neurology, Royal Brisbane Hospital, Queensland, Australia.; University of Queensland, Australia., Nytrova P; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic., Boz C; Department of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey., Surcinelli A; Department of Neuroscience, MS Center, Neurology Unit, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Kalincik T; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Victoria, Australia.; CORe, Department of Medicine, University of Melbourne, Victoria, Australia., Patti F; Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia, Catania, Italy.; Multiple Sclerosis Unit, AOU Policlinico G Rodolico-San Marco, University of Catania, Italy; and., Huda S; Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.; Department of Pharmacology and Therapeutics, University of Liverpool, United Kingdom., Butzkueven H; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia., Monif M; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.
Corporate Authors: MSBase Investigators
Source: Neurology [Neurology] 2026 Apr 14; Vol. 106 (7), pp. e214707. Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder.
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  Data: <searchLink fieldCode="AU" term="%22Siriratnam+P%22">Siriratnam P</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.; Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jokubaitis+VG%22">Jokubaitis VG</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Van+Der+Walt+A%22">Van Der Walt A</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sanfilippo+PG%22">Sanfilippo PG</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, The Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Etemadifar+M%22">Etemadifar M</searchLink>; Department of Neurology, DrEtemadifar MS Institute, Isfahan University of Medical Sciences, Iran.; Faculty of Medicine, Isfahan University of Medical Sciences, Iran.<br /><searchLink fieldCode="AU" term="%22Altintas+A%22">Altintas A</searchLink>; Department of Neurology, School of Medicine and Koc University Research Center for Translational Medicine (KUTTAM), Koc University, School of Medicine, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Al-Asmi+A%22">Al-Asmi A</searchLink>; College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khodh, Oman.<br /><searchLink fieldCode="AU" term="%22Laureys+G%22">Laureys G</searchLink>; Department of Neurology, Universitary Hospital Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Meca-Lallana+JE%22">Meca-Lallana JE</searchLink>; Neurology Department, Multiple Sclerosis CSUR and Clinical Neuroimmunology Unit, Neurology Department, Virgen de la Arrixaca Clinical University Hospital (IMIB-Arrixaca), Murcia, Spain.; NICEM Cathedra. 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UCAM-San Antonio Catholic University, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Roos+I%22">Roos I</searchLink>; Neuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Victoria, Australia.; CORe, Department of Medicine, University of Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mccombe+PA%22">Mccombe PA</searchLink>; Department of Neurology, Royal Brisbane Hospital, Queensland, Australia.; University of Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Nytrova+P%22">Nytrova P</searchLink>; Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Boz+C%22">Boz C</searchLink>; Department of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.<br /><searchLink fieldCode="AU" term="%22Surcinelli+A%22">Surcinelli A</searchLink>; Department of Neuroscience, MS Center, Neurology Unit, S. 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