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Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment.

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Title: Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment.
Authors: Jara C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.; Facultad de Salud y Ciencias Sociales, Universidad de Las Américas, Santiago, Chile., Venegas-Zamora L; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile., Park-Kang HS; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile., Lira M; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile., Ricca M; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile., Valenzuela S; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.; Facultad de Medicina Veterinaria, Universidad San Sebastián, Santiago, Chile., Tapia-Rojas C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile. cheril.tapia@uss.cl.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile. cheril.tapia@uss.cl.
Source: Npj aging [NPJ Aging] 2026 Mar 05; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment.
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  Data: <searchLink fieldCode="AU" term="%22Jara+C%22">Jara C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.; Facultad de Salud y Ciencias Sociales, Universidad de Las Américas, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Venegas-Zamora+L%22">Venegas-Zamora L</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Park-Kang+HS%22">Park-Kang HS</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Lira+M%22">Lira M</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ricca+M%22">Ricca M</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Valenzuela+S%22">Valenzuela S</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.; Facultad de Medicina Veterinaria, Universidad San Sebastián, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Tapia-Rojas+C%22">Tapia-Rojas C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile. cheril.tapia@uss.cl.; Facultad de Ciencias, Universidad San Sebastián, Santiago, Chile. cheril.tapia@uss.cl.
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  Data: <searchLink fieldCode="JN" term="%229918402285106676%22">Npj aging</searchLink> [NPJ Aging] 2026 Mar 05; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918402285106676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-6068 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227316068%22">27316068 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Aging <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41514-026-00351-3
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        Text: English
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      – TitleFull: Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment.
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              Text: 2026 Mar 05
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              Y: 2026
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