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Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.

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Title: Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.
Authors: Moiseyenko A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. anamois@caltech.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. anamois@caltech.edu., Antonello G; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy., Schonhoff AM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Boktor JC; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Long K; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy., Dirks B; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA., Oguienko AD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Winnett AV; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; UCLA-Caltech Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA, USA., Simpson P; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Daeizadeh D; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA., Ismagilov RF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Krajmalnik-Brown R; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA.; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ, USA., Segata N; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy., Waldron LD; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy., Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. sarkis@caltech.edu.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Mar 05; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.
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  Data: <searchLink fieldCode="AU" term="%22Moiseyenko+A%22">Moiseyenko A</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. anamois@caltech.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. anamois@caltech.edu.<br /><searchLink fieldCode="AU" term="%22Antonello+G%22">Antonello G</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Schonhoff+AM%22">Schonhoff AM</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Boktor+JC%22">Boktor JC</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Long+K%22">Long K</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Dirks+B%22">Dirks B</searchLink>; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Oguienko+AD%22">Oguienko AD</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Winnett+AV%22">Winnett AV</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; UCLA-Caltech Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Simpson+P%22">Simpson P</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Daeizadeh+D%22">Daeizadeh D</searchLink>; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ismagilov+RF%22">Ismagilov RF</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Krajmalnik-Brown+R%22">Krajmalnik-Brown R</searchLink>; Biodesign Center for Health through Microbiomes, Arizona State University, Tempe, AZ, USA.; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Segata+N%22">Segata N</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Waldron+LD%22">Waldron LD</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.; Department of Epidemiology and Biostatistics and Institute for Implementation Science in Population Health, Graduate School of Public Health and Health Policy, City University of New York (CUNY), New York, NY, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Povo, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Mazmanian+SK%22">Mazmanian SK</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. sarkis@caltech.edu.
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