Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.

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Title: Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.
Authors: Yang T; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Ay Y; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Kaur S; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Butler RR 3rd; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Tran KC; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Liu H; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Langness VF; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Massa SM; Department of Neurology, San Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu.; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu., Longo FM; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA. flongo@stanford.edu.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA. flongo@stanford.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-5960
DOI:10.1186/s40478-026-02263-5