Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.

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Title: Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.
Authors: Schröder LJ; Institute for Pathology, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de., Rückoldt J; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Schubert S; Institute for Pathology, Hannover Medical School, Hannover, Germany., Knudsen L; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany., Janciauskiene SM; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Werlein C; Institute for Pathology, Hannover Medical School, Hannover, Germany., Knoll M; Institute for Pathology, Hannover Medical School, Hannover, Germany., Engelhardt R; Institute for Pathology, Hannover Medical School, Hannover, Germany., Petzold-Mügge C; Institute for Pathology, Hannover Medical School, Hannover, Germany., Schupp JC; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Hoeper MM; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Gottlieb J; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Ius F; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Zardo P; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Lindenberg M; Institute for Medical Microbiology, Hannover Medical School, Hannover, Germany., Riehle C; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Neubert L; Institute for Pathology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany., Kamp JC; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.
Source: Respiratory research [Respir Res] 2026 Mar 07; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1465-993X
DOI:10.1186/s12931-026-03610-9