Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.

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Title: Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.
Authors: Diaz M; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gull N; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Peng PC; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Dabke K; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Baker J; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Sun J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Alvarado J; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Bastin B; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Mazumdar N; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Santiskulvong C; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Li AJ; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Karlan BY; Department of Obstetrics and Gynecology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90048, USA., Rimel BJ; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Parker SJ; Proteomic and Metabolomics Core Facility at the Board of Governors Innovation Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gayther SA; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Center for Inherited Oncogenesis, Department of Medicine, UT Health San Antonio, San Antonio, TX, 78229, USA., Jones MR; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 06; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-07951-3