View in EDS

Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.

Saved in:
Bibliographic Details
Title: Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.
Authors: Diaz M; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gull N; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Peng PC; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Dabke K; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Baker J; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Sun J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Alvarado J; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Bastin B; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Mazumdar N; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Santiskulvong C; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Li AJ; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Karlan BY; Department of Obstetrics and Gynecology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90048, USA., Rimel BJ; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Parker SJ; Proteomic and Metabolomics Core Facility at the Board of Governors Innovation Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gayther SA; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Center for Inherited Oncogenesis, Department of Medicine, UT Health San Antonio, San Antonio, TX, 78229, USA., Jones MR; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 06; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41792798
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Diaz+M%22">Diaz M</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Gull+N%22">Gull N</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Peng+PC%22">Peng PC</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Dabke+K%22">Dabke K</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Baker+J%22">Baker J</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Alvarado+J%22">Alvarado J</searchLink>; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Bastin+B%22">Bastin B</searchLink>; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Mazumdar+N%22">Mazumdar N</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Santiskulvong+C%22">Santiskulvong C</searchLink>; Applied Genomics, Computation and Translation Core, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Li+AJ%22">Li AJ</searchLink>; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Karlan+BY%22">Karlan BY</searchLink>; Department of Obstetrics and Gynecology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Rimel+BJ%22">Rimel BJ</searchLink>; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Parker+SJ%22">Parker SJ</searchLink>; Proteomic and Metabolomics Core Facility at the Board of Governors Innovation Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.<br /><searchLink fieldCode="AU" term="%22Gayther+SA%22">Gayther SA</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Center for Inherited Oncogenesis, Department of Medicine, UT Health San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Jones+MR%22">Jones MR</searchLink>; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. michelle.jones@csmc.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Mar 06; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 06.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41792798
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s12967-026-07951-3
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Diaz M
      – PersonEntity:
          Name:
            NameFull: Gull N
      – PersonEntity:
          Name:
            NameFull: Peng PC
      – PersonEntity:
          Name:
            NameFull: Dabke K
      – PersonEntity:
          Name:
            NameFull: Baker J
      – PersonEntity:
          Name:
            NameFull: Sun J
      – PersonEntity:
          Name:
            NameFull: Alvarado J
      – PersonEntity:
          Name:
            NameFull: Bastin B
      – PersonEntity:
          Name:
            NameFull: Mazumdar N
      – PersonEntity:
          Name:
            NameFull: Santiskulvong C
      – PersonEntity:
          Name:
            NameFull: Li AJ
      – PersonEntity:
          Name:
            NameFull: Karlan BY
      – PersonEntity:
          Name:
            NameFull: Rimel BJ
      – PersonEntity:
          Name:
            NameFull: Parker SJ
      – PersonEntity:
          Name:
            NameFull: Gayther SA
      – PersonEntity:
          Name:
            NameFull: Jones MR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 03
              Text: 2026 Mar 06
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1479-5876
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of translational medicine
              Type: main
ResultId 1