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Targeted KEAP1 disruption enhances antioxidant defense and mesenchymal stromal cell therapy for chronic limb-threatening ischemia.

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Title: Targeted KEAP1 disruption enhances antioxidant defense and mesenchymal stromal cell therapy for chronic limb-threatening ischemia.
Authors: Shin EJ; ToolGen, Inc., Seoul, Republic of Korea., Choi Y; ToolGen, Inc., Seoul, Republic of Korea., Jeon EJ; Cellartgen, Inc., Seoul 03722, Republic of Korea., Lee KI; ToolGen, Inc., Seoul, Republic of Korea., Lee KJ; ToolGen, Inc., Seoul, Republic of Korea., Son YJ; ToolGen, Inc., Seoul, Republic of Korea., Son MJ; ToolGen, Inc., Seoul, Republic of Korea., Kim S; ToolGen, Inc., Seoul, Republic of Korea., Cho SW; Cellartgen, Inc., Seoul 03722, Republic of Korea; Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea. Electronic address: seungwoocho@yonsei.ac.kr., Lee JY; ToolGen, Inc., Seoul, Republic of Korea; Department of Health Science and Technology, Samsung Advanced Institute of Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Republic of Korea; Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea. Electronic address: jyjlee0930@gmail.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3949-3961. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.03.005