Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

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Title: Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.
Authors: Jumentier B; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Qu HQ; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lu T; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA., Liu K; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Kleinbrink EL; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., Klein K; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., Belbellaj W; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Gamache I; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Ferrat L; Faculty of Medicine, Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland., Butler-Laporte G; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Hakonarson H; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Wu W; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Polychronakos C; Endocrine Genetics Laboratory, Research Institute of McGill University Health Centre, Montreal, QC, Canada., Greenwood CMT; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada., Manousaki D; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Pediatrics, Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.
Source: Diabetologia [Diabetologia] 2026 Jun; Vol. 69 (6), pp. 1557-1568. Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0428
DOI:10.1007/s00125-026-06706-5