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Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

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Title: Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.
Authors: Jumentier B; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Qu HQ; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lu T; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA., Liu K; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Kleinbrink EL; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., Klein K; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada., Belbellaj W; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Gamache I; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada., Ferrat L; Faculty of Medicine, Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland., Butler-Laporte G; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li Y; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Hakonarson H; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Wu W; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China., Polychronakos C; Endocrine Genetics Laboratory, Research Institute of McGill University Health Centre, Montreal, QC, Canada., Greenwood CMT; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada., Manousaki D; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Pediatrics, Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.
Source: Diabetologia [Diabetologia] 2026 Jun; Vol. 69 (6), pp. 1557-1568. Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Jumentier+B%22">Jumentier B</searchLink>; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Qu+HQ%22">Qu HQ</searchLink>; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Kleinbrink+EL%22">Kleinbrink EL</searchLink>; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Klein+K%22">Klein K</searchLink>; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Belbellaj+W%22">Belbellaj W</searchLink>; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Gamache+I%22">Gamache I</searchLink>; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ferrat+L%22">Ferrat L</searchLink>; Faculty of Medicine, Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Butler-Laporte+G%22">Butler-Laporte G</searchLink>; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Hakonarson+H%22">Hakonarson H</searchLink>; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Polychronakos+C%22">Polychronakos C</searchLink>; Endocrine Genetics Laboratory, Research Institute of McGill University Health Centre, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Greenwood+CMT%22">Greenwood CMT</searchLink>; Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Manousaki+D%22">Manousaki D</searchLink>; Research Center of the Sainte-Justine University Hospital, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Pediatrics, Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada. Despina.manousaki@umontreal.ca.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2026 Jun; Vol. 69 (6), pp. 1557-1568. <i>Date of Electronic Publication: </i>2026 Mar 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00125-026-06706-5
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        Text: English
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