Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia.

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Bibliographic Details
Title: Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia.
Authors: Chen H; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Jin S; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China., Liu M; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, 510623, China., Zhu Y; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Zhang L; Department of Neurology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China., Li C; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Liu P; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China., Tong X; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. xtong@shsmu.edu.cn.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China. xtong@shsmu.edu.cn.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China. xtong@shsmu.edu.cn., Zhu Z; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Zzqheart2025@126.com.
Source: Neuroscience bulletin [Neurosci Bull] 2026 Jun; Vol. 42 (6), pp. 1199-1217. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1995-8218
DOI:10.1007/s12264-026-01602-9