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Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia.

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Title: Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia.
Authors: Chen H; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Jin S; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China., Liu M; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, 510623, China., Zhu Y; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Zhang L; Department of Neurology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China., Li C; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China., Liu P; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China., Tong X; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. xtong@shsmu.edu.cn.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China. xtong@shsmu.edu.cn.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China. xtong@shsmu.edu.cn., Zhu Z; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Zzqheart2025@126.com.
Source: Neuroscience bulletin [Neurosci Bull] 2026 Jun; Vol. 42 (6), pp. 1199-1217. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia.
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  Data: <searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.<br /><searchLink fieldCode="AU" term="%22Jin+S%22">Jin S</searchLink>; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China.; Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, 510623, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Neurology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China.<br /><searchLink fieldCode="AU" term="%22Tong+X%22">Tong X</searchLink>; Department of Obstetrics and Gynecology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. xtong@shsmu.edu.cn.; Department of Anatomy and Physiology, School of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 201318, China. xtong@shsmu.edu.cn.; Key Laboratory of Molecular Neurobiology, Ministry of Education, Navy Military Medical University, Shanghai, 200433, China. xtong@shsmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Zzqheart2025@126.com.
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  Data: <searchLink fieldCode="JN" term="%22101256850%22">Neuroscience bulletin</searchLink> [Neurosci Bull] 2026 Jun; Vol. 42 (6), pp. 1199-1217. <i>Date of Electronic Publication: </i>2026 Mar 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>101256850 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1995-8218 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219958218%22">19958218 </searchLink><i>NLM ISO Abbreviation: </i>Neurosci Bull <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12264-026-01602-9
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              Text: 2026 Jun
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              Y: 2026
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