Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.

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Title: Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.
Authors: Xu CL; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Zhao LH; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Tang J; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Song XH; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China., Dou Z; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China., Wang YJ; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Deqing, China.
Source: Biotechnology and bioengineering [Biotechnol Bioeng] 2026 May; Vol. 123 (5), pp. 1380-1392. Date of Electronic Publication: 2026 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-0290
DOI:10.1002/bit.70183