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Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.

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Title: Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.
Authors: Xu CL; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Zhao LH; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Tang J; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China., Song XH; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China., Dou Z; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China., Wang YJ; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Deqing, China.
Source: Biotechnology and bioengineering [Biotechnol Bioeng] 2026 May; Vol. 123 (5), pp. 1380-1392. Date of Electronic Publication: 2026 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.
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  Data: <searchLink fieldCode="AU" term="%22Xu+CL%22">Xu CL</searchLink>; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+LH%22">Zhao LH</searchLink>; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.<br /><searchLink fieldCode="AU" term="%22Song+XH%22">Song XH</searchLink>; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Dou+Z%22">Dou Z</searchLink>; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+YJ%22">Wang YJ</searchLink>; Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs, Deqing, China.; Key Laboratory for Green Pharmaceutical Technology and Equipment (Zhejiang University of Technology) of Ministry of Education, Deqing, China.; College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Deqing, China.
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  Data: <searchLink fieldCode="JN" term="%227502021%22">Biotechnology and bioengineering</searchLink> [Biotechnol Bioeng] 2026 May; Vol. 123 (5), pp. 1380-1392. <i>Date of Electronic Publication: </i>2026 Mar 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7502021 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200063592%22">00063592 </searchLink><i>NLM ISO Abbreviation: </i>Biotechnol Bioeng <i>Subsets: </i>MEDLINE
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        Value: 10.1002/bit.70183
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        Text: English
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      – TitleFull: Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones.
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              M: 05
              Text: 2026 May
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