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Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.

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Title: Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.
Authors: Krebs AS; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA., Lazarov T; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Reynolds AT; Department of Medicine, University of Washington, Seattle, Washington, USA., Dill-McFarland KA; Department of Medicine, University of Washington, Seattle, Washington, USA., Xie A; Cell Biology Program, Sloan Kettering Institute, New York, New York, USA.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, USA., Bean JM; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Du M; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA., Levy O; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Buglino JA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Zhong A; The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute, New York, New York, USA., Neehus AL; Rockefeller University, New York, New York, USA., Boisson-Dupuis S; Rockefeller University, New York, New York, USA., Casanova JL; Rockefeller University, New York, New York, USA., Kroon EE; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Möller M; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa.; National Institute for Theoretical and Computational Sciences (NITheCS) South Africa.; Genomics for Health in Africa (GHA), Africa-Europe Cluster of Research Excellence (CoRE), Ghana., Hawn TR; Department of Medicine, University of Washington, Seattle, Washington, USA., Zhou T; The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute, New York, New York, USA., Finley LW; Cell Biology Program, Sloan Kettering Institute, New York, New York, USA., Jean Juste MA; GHESKIO Center, Port Au Prince, Haiti., Fitzgerald DW; GHESKIO Center, Port Au Prince, Haiti.; Center for Global Health, Weill Cornell Medicine, New York, New York, USA., Geissmann F; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA., Glickman MS; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.
Source: JCI insight [JCI Insight] 2026 Mar 09; Vol. 11 (5). Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.
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  Data: <searchLink fieldCode="AU" term="%22Krebs+AS%22">Krebs AS</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lazarov+T%22">Lazarov T</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Reynolds+AT%22">Reynolds AT</searchLink>; Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Dill-McFarland+KA%22">Dill-McFarland KA</searchLink>; Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Xie+A%22">Xie A</searchLink>; Cell Biology Program, Sloan Kettering Institute, New York, New York, USA.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Bean+JM%22">Bean JM</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Du+M%22">Du M</searchLink>; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Levy+O%22">Levy O</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Buglino+JA%22">Buglino JA</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+A%22">Zhong A</searchLink>; The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Neehus+AL%22">Neehus AL</searchLink>; Rockefeller University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Boisson-Dupuis+S%22">Boisson-Dupuis S</searchLink>; Rockefeller University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; Rockefeller University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kroon+EE%22">Kroon EE</searchLink>; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Möller+M%22">Möller M</searchLink>; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa.; National Institute for Theoretical and Computational Sciences (NITheCS) South Africa.; Genomics for Health in Africa (GHA), Africa-Europe Cluster of Research Excellence (CoRE), Ghana.<br /><searchLink fieldCode="AU" term="%22Hawn+TR%22">Hawn TR</searchLink>; Department of Medicine, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Finley+LW%22">Finley LW</searchLink>; Cell Biology Program, Sloan Kettering Institute, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Jean+Juste+MA%22">Jean Juste MA</searchLink>; GHESKIO Center, Port Au Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+DW%22">Fitzgerald DW</searchLink>; GHESKIO Center, Port Au Prince, Haiti.; Center for Global Health, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Geissmann+F%22">Geissmann F</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Glickman+MS%22">Glickman MS</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Mar 09; Vol. 11 (5). <i>Date of Electronic Publication: </i>2026 Mar 09 (<i>Print Publication: </i>2026).
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