Allicin inhibits PD-L1 through the IL-6/JAK2/STAT3 pathway to suppress immune evasion in osteosarcoma.

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Title: Allicin inhibits PD-L1 through the IL-6/JAK2/STAT3 pathway to suppress immune evasion in osteosarcoma.
Authors: Gong R; First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China., Jin XM; First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China., Cui X; First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China., Sun JH; First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China., Xie WP; Department of Orthopedic Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China., Zhang YK; Department of Orthopedic Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 20; Vol. 17, pp. 1735090. Date of Electronic Publication: 2026 Feb 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1735090