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Extracellular vesicle-encapsulated microRNA-425 promotes tumor development and serves as a biomarker for pancreatic ductal adenocarcinoma.

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Title: Extracellular vesicle-encapsulated microRNA-425 promotes tumor development and serves as a biomarker for pancreatic ductal adenocarcinoma.
Authors: Koyama K; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Takahashi K; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan. t-kenji@asahikawa-med.ac.jp.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. t-kenji@asahikawa-med.ac.jp., Ono Y; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Oyama K; Department of Cardiac Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan., Tamamura N; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Tanaka H; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Asai F; H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan., Kobayashi Y; Department of Pharmacology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan., Maeda C; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan., Ohtaki Y; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan., Sato H; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Okada T; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Kawabata H; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Iwamoto H; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Kitano Y; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Itoh T; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan., Matsuda A; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan., Inuzuka T; H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan., Taniue K; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Isotope Science Center, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan., Nakayama K; Department of Pharmacology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan., Fujiya M; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Okumura T; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan., Mizukami Y; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Source: Journal of gastroenterology [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 660-672. Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Extracellular vesicle-encapsulated microRNA-425 promotes tumor development and serves as a biomarker for pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Koyama+K%22">Koyama K</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+K%22">Takahashi K</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan. t-kenji@asahikawa-med.ac.jp.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. t-kenji@asahikawa-med.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ono+Y%22">Ono Y</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Oyama+K%22">Oyama K</searchLink>; Department of Cardiac Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Tamamura+N%22">Tamamura N</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+H%22">Tanaka H</searchLink>; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Asai+F%22">Asai F</searchLink>; H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+Y%22">Kobayashi Y</searchLink>; Department of Pharmacology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Maeda+C%22">Maeda C</searchLink>; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Ohtaki+Y%22">Ohtaki Y</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+H%22">Sato H</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+T%22">Okada T</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Kawabata+H%22">Kawabata H</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Iwamoto+H%22">Iwamoto H</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Kitano+Y%22">Kitano Y</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Itoh+T%22">Itoh T</searchLink>; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+A%22">Matsuda A</searchLink>; Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Inuzuka+T%22">Inuzuka T</searchLink>; H.U. Group Research Institute G.K., Akiruno, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Taniue+K%22">Taniue K</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Isotope Science Center, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+K%22">Nakayama K</searchLink>; Department of Pharmacology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiya+M%22">Fujiya M</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Okumura+T%22">Okumura T</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Mizukami+Y%22">Mizukami Y</searchLink>; Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, 2-1-1-1, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan.; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, Japan.; Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 660-672. <i>Date of Electronic Publication: </i>2026 Mar 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9430794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-5922 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209441174%22">09441174 </searchLink><i>NLM ISO Abbreviation: </i>J Gastroenterol <i>Subsets: </i>MEDLINE
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