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Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.

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Title: Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.
Authors: Buco PAV; Centre for Innate Immunity and Infection Diseases, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia.; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia., Castillo-Tandazo W; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia., Chalk AM; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia., Pilcher C; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; School of Science, STEM College, RMIT University, Melbourne, Victoria, 3083, Australia., Holien JK; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; School of Science, STEM College, RMIT University, Melbourne, Victoria, 3083, Australia., Heierhorst J; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia., Tan TY; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, 3052, Australia., Koren A; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Smeets MF; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia., Walkley CR; Centre for Innate Immunity and Infection Diseases, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia. carl.walkley@hudson.org.au.; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia. carl.walkley@hudson.org.au.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia. carl.walkley@hudson.org.au.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, 3168, Australia. carl.walkley@hudson.org.au.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia. carl.walkley@hudson.org.au.
Source: EMBO reports [EMBO Rep] 2026 Apr; Vol. 27 (7), pp. 1759-1788. Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication.
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  Data: <searchLink fieldCode="AU" term="%22Buco+PAV%22">Buco PAV</searchLink>; Centre for Innate Immunity and Infection Diseases, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia.; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Castillo-Tandazo+W%22">Castillo-Tandazo W</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Chalk+AM%22">Chalk AM</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Pilcher+C%22">Pilcher C</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; School of Science, STEM College, RMIT University, Melbourne, Victoria, 3083, Australia.<br /><searchLink fieldCode="AU" term="%22Holien+JK%22">Holien JK</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; School of Science, STEM College, RMIT University, Melbourne, Victoria, 3083, Australia.<br /><searchLink fieldCode="AU" term="%22Heierhorst+J%22">Heierhorst J</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Tan+TY%22">Tan TY</searchLink>; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Victoria, 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Koren+A%22">Koren A</searchLink>; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.<br /><searchLink fieldCode="AU" term="%22Smeets+MF%22">Smeets MF</searchLink>; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia.<br /><searchLink fieldCode="AU" term="%22Walkley+CR%22">Walkley CR</searchLink>; Centre for Innate Immunity and Infection Diseases, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia. carl.walkley@hudson.org.au.; St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia. carl.walkley@hudson.org.au.; Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, 3065, Australia. carl.walkley@hudson.org.au.; Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, 3168, Australia. carl.walkley@hudson.org.au.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia. carl.walkley@hudson.org.au.
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        Value: 10.1038/s44319-026-00727-2
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              Text: 2026 Apr
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