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A Novel Anks6 Nonsense Variant Promotes Polycystic Kidney Disease in Han:SPRD-Cy Rats and its Homozygosity is Prenatally Lethal.

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Title: A Novel Anks6 Nonsense Variant Promotes Polycystic Kidney Disease in Han:SPRD-Cy Rats and its Homozygosity is Prenatally Lethal.
Authors: Pemberton TJ; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Winter T; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Canadian Centre for Research in Agri-Food Research in Health and Medicine, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada., Hemming R; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Blant A; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Fresnoza AL; Central Animal Care Services, University of Manitoba, Winnipeg, Manitoba, Canada., Barker EN; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Ashiri M; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Xiang B; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada., Dolinsky VW; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada., Triggs-Raine B; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Aukema HM; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.; Canadian Centre for Research in Agri-Food Research in Health and Medicine, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Source: Kidney360 [Kidney360] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 101766381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2641-7650 (Electronic) Linking ISSN: 26417650 NLM ISO Abbreviation: Kidney360 Subsets: MEDLINE
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              Text: 2026 Mar 11
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