Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial.

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Title: Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial.
Authors: Gao L; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China., Zhai X; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China., Wang N; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China., Liao N; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China., Xiao P; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Xu F; Department of Pediatrics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China., Yang M; Department of Pediatrics, The Third Xiangya Hospital of Central South University, Central South University, Changsha, China., Xu X; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China., An Q; Department of Hematology and Oncology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China., Luo J; Department of Hematology and Oncology, Kaifeng Children's Hospital, Kaifeng, China., Yang L; Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China., Yuan X; Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China., He Y; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China., Zhuang Y; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China., Wang H; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China., Yang L; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China., Zhang W; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Liu Y; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China., Li J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., He H; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Wang Y; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN., Lu J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Jiang H; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Ju X; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China., Wang QF; China National Center for Bioinformation, Beijing, China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; School of Future Technology, University of Chinese Academy of Sciences, Beijing, China., Ribeiro RC; Division of Leukemia/Lymphoma, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN., Hu S; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China.; Pediatric Hematology & Oncology Center of Jiangsu Province, Suzhou, China.
Source: Blood [Blood] 2026 Jul 02; Vol. 148 (1), pp. 71-83.
Publication Type: Equivalence Trial; Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-0020
DOI:10.1182/blood.2025030972