Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses.
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| Title: | Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses. |
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| Authors: | Cui W; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Li Q; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.; MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, 310058, Hangzhou, China., Wei J; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Zhou T; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.; MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, 310058, Hangzhou, China., Zhu H; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Huang D; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China.; Department of Biology, University of Virginia, Charlottesville, VA, 22904, USA., Wang S; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Gao J; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Zhou R; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Sun Z; Jinan Microecological Biomedicine Shandong Laboratory, Jinan, 250117, China.; Yuhang Institute of Medical Science Innovation and Transformation, 310058, Hangzhou, China., Ruan H; Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, State Key Laboratory Breeding Base of Eco-Environments and Bio-Resources of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, 400715, Chongqing, China., Lo LJ; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Tao T; Pediatric Cancer Research Center, National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital Zhejiang University School of Medicine, 310052, Hangzhou, China.; Department of Surgical Oncology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, 310052, Hangzhou, China., Chen J; College of Life Sciences, Zhejiang University, 310058, Hangzhou, China., Peng J; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China., Shi H; MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Animal Sciences, Zhejiang University, 310058, Hangzhou, China. hui_shi@zju.edu.cn.; MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, 310058, Hangzhou, China. hui_shi@zju.edu.cn. |
| Source: | The EMBO journal [EMBO J] 2026 Apr; Vol. 45 (8), pp. 2561-2586. Date of Electronic Publication: 2026 Mar 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-026-00729-9 |
