Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial.
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| Title: | Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial. |
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| Authors: | Papaioannou A; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Kennedy C; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Lee J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Hewston P; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., McArthur C; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada., Maharaj S; Hamilton Health Sciences, Hamilton, Ontario, Canada., Adachi J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Boulos P; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Bobba R; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Rabinovich A; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., McKenna B; Escarpment Health Centre, Hamilton, Ontario, Canada., Palubiski L; Escarpment Health Centre, Hamilton, Ontario, Canada., Mangin D; Department of Family Medicine, University of Otago, Christchurch, New Zealand., Thabane L; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa., Marr S; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Kaasalainen S; School of Nursing, McMaster University, Hamilton, Ontario, Canada., Tarride JÉ; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada.; Programs for Assessment of Technology in Health, The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, Canada., Theou O; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Armstrong D; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Negm A; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Noseworthy M; School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, Canada., Rockwood K; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Dolovich L; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Abu Alrob H; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Hladysh G; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.; YMCA of Hamilton/Burlington/Brantford, Hamilton, Ontario, Canada., Thompson K; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Ioannidis G; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada. |
| Source: | PloS one [PLoS One] 2026 Mar 12; Vol. 21 (3), pp. e0343338. Date of Electronic Publication: 2026 Mar 12 (Print Publication: 2026). |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41818185 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Papaioannou+A%22">Papaioannou A</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kennedy+C%22">Kennedy C</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hewston+P%22">Hewston P</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McArthur+C%22">McArthur C</searchLink>; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Maharaj+S%22">Maharaj S</searchLink>; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Adachi+J%22">Adachi J</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Boulos+P%22">Boulos P</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bobba+R%22">Bobba R</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rabinovich+A%22">Rabinovich A</searchLink>; Department of Surgery, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22McKenna+B%22">McKenna B</searchLink>; Escarpment Health Centre, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Palubiski+L%22">Palubiski L</searchLink>; Escarpment Health Centre, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mangin+D%22">Mangin D</searchLink>; Department of Family Medicine, University of Otago, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Thabane+L%22">Thabane L</searchLink>; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Marr+S%22">Marr S</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kaasalainen+S%22">Kaasalainen S</searchLink>; School of Nursing, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tarride+JÉ%22">Tarride JÉ</searchLink>; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada.; Programs for Assessment of Technology in Health, The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Theou+O%22">Theou O</searchLink>; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Armstrong+D%22">Armstrong D</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Negm+A%22">Negm A</searchLink>; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Noseworthy+M%22">Noseworthy M</searchLink>; School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rockwood+K%22">Rockwood K</searchLink>; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.<br /><searchLink fieldCode="AU" term="%22Dolovich+L%22">Dolovich L</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Abu+Alrob+H%22">Abu Alrob H</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hladysh+G%22">Hladysh G</searchLink>; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.; YMCA of Hamilton/Burlington/Brantford, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Thompson+K%22">Thompson K</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ioannidis+G%22">Ioannidis G</searchLink>; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Mar 12; Vol. 21 (3), pp. e0343338. <i>Date of Electronic Publication: </i>2026 Mar 12 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41818185 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0343338 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0343338 Titles: – TitleFull: Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Papaioannou A – PersonEntity: Name: NameFull: Kennedy C – PersonEntity: Name: NameFull: Lee J – PersonEntity: Name: NameFull: Hewston P – PersonEntity: Name: NameFull: McArthur C – PersonEntity: Name: NameFull: Maharaj S – PersonEntity: Name: NameFull: Adachi J – PersonEntity: Name: NameFull: Boulos P – PersonEntity: Name: NameFull: Bobba R – PersonEntity: Name: NameFull: Rabinovich A – PersonEntity: Name: NameFull: McKenna B – PersonEntity: Name: NameFull: Palubiski L – PersonEntity: Name: NameFull: Mangin D – PersonEntity: Name: NameFull: Thabane L – PersonEntity: Name: NameFull: Marr S – PersonEntity: Name: NameFull: Kaasalainen S – PersonEntity: Name: NameFull: Tarride JÉ – PersonEntity: Name: NameFull: Theou O – PersonEntity: Name: NameFull: Armstrong D – PersonEntity: Name: NameFull: Negm A – PersonEntity: Name: NameFull: Noseworthy M – PersonEntity: Name: NameFull: Rockwood K – PersonEntity: Name: NameFull: Dolovich L – PersonEntity: Name: NameFull: Abu Alrob H – PersonEntity: Name: NameFull: Hladysh G – PersonEntity: Name: NameFull: Thompson K – PersonEntity: Name: NameFull: Ioannidis G IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 03 Text: 2026 Mar 12 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1932-6203 Numbering: – Type: volume Value: 21 – Type: issue Value: 3 Titles: – TitleFull: PloS one Type: main |
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