Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy.

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Title: Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy.
Authors: He C; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory of Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, MA, USA., Amodio M; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA. orr@broadinstitute.org.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. orr@broadinstitute.org., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA., Xavier RJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. rxavier@broadinstitute.org.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rxavier@broadinstitute.org.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rxavier@broadinstitute.org., Uhler C; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA. cuhler@mit.edu.; Laboratory of Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA. cuhler@mit.edu.; Institute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, MA, USA. cuhler@mit.edu.
Source: Nature communications [Nat Commun] 2026 Mar 12; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-70505-0