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Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.

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Title: Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.
Authors: Lee SJ; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea., Nam BG; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Hong SA; Divison of Bio Research, SK Bioscience, Seongnam-si, Republic of Korea., Jo DH; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee SM; Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Incheon, Republic of Korea. lsm10003@gmail.com.; Department of Ophthalmology, Catholic Kwandong University College of Medicine, Gangneung-si, Republic of Korea. lsm10003@gmail.com., Bae S; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr., Kim JH; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.; Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.
Source: Gene therapy [Gene Ther] 2026 Mar 12. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5462
DOI:10.1038/s41434-026-00607-3