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Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.

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Title: Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.
Authors: Lee SJ; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea., Nam BG; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Hong SA; Divison of Bio Research, SK Bioscience, Seongnam-si, Republic of Korea., Jo DH; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee SM; Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Incheon, Republic of Korea. lsm10003@gmail.com.; Department of Ophthalmology, Catholic Kwandong University College of Medicine, Gangneung-si, Republic of Korea. lsm10003@gmail.com., Bae S; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr., Kim JH; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.; Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.
Source: Gene therapy [Gene Ther] 2026 Mar 12. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
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  Data: Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.
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  Data: <searchLink fieldCode="AU" term="%22Lee+SJ%22">Lee SJ</searchLink>; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nam+BG%22">Nam BG</searchLink>; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+SA%22">Hong SA</searchLink>; Divison of Bio Research, SK Bioscience, Seongnam-si, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jo+DH%22">Jo DH</searchLink>; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea.; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SM%22">Lee SM</searchLink>; Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Incheon, Republic of Korea. lsm10003@gmail.com.; Department of Ophthalmology, Catholic Kwandong University College of Medicine, Gangneung-si, Republic of Korea. lsm10003@gmail.com.<br /><searchLink fieldCode="AU" term="%22Bae+S%22">Bae S</searchLink>; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. sbae7@snu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Global Excellence Center for Gene & Cell Therapy (GEC-GCT), Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. steph25@snu.ac.kr.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.; Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Republic of Korea. steph25@snu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%229421525%22">Gene therapy</searchLink> [Gene Ther] 2026 Mar 12. <i>Date of Electronic Publication: </i>2026 Mar 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421525 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5462 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209697128%22">09697128 </searchLink><i>NLM ISO Abbreviation: </i>Gene Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41434-026-00607-3
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              Text: 2026 Mar 12
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