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Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.

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Title: Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.
Authors: Khan NU; Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Peshawar, 25130, Pakistan., Lei H; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China., Fu J; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.; Postgraduate Training Base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital), Wenzhou, 325000, China., Lei R; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China., Chen X; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China., Alqarni SS; Department of Clinical Laboratory Science, College of Applied Medical Science, King Saud University, Riyadh, 11421, Saudi Arabia., Chen T; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China. chenth@zjcc.org.cn.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China. chenth@zjcc.org.cn.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 12; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 12.
Publication Type: Systematic Review; Journal Article; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Khan+NU%22">Khan NU</searchLink>; Institute of Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Peshawar, 25130, Pakistan.<br /><searchLink fieldCode="AU" term="%22Lei+H%22">Lei H</searchLink>; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.; Postgraduate Training Base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital), Wenzhou, 325000, China.<br /><searchLink fieldCode="AU" term="%22Lei+R%22">Lei R</searchLink>; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China.<br /><searchLink fieldCode="AU" term="%22Alqarni+SS%22">Alqarni SS</searchLink>; Department of Clinical Laboratory Science, College of Applied Medical Science, King Saud University, Riyadh, 11421, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou, 310022, China. chenth@zjcc.org.cn.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, 310018, China. chenth@zjcc.org.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Mar 12; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 12.
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  Data: Systematic Review; Journal Article; Meta-Analysis
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-07997-3
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        Text: English
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      – TitleFull: Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.
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              Text: 2026 Mar 12
              Type: published
              Y: 2026
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