Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.

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Title: Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.
Authors: Hardet R; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France., Wang SH; Topas Therapeutics GmbH, Hamburg, Germany., Delignat S; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France., Blandin M; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France., Digigow R; Topas Therapeutics GmbH, Hamburg, Germany., Gottwick C; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Heine M; Department of Biochemistry and Molecular Cell Biology (N30), University Medical Clinic Hamburg-Eppendorf, Hamburg, Germany., Marques Mesquita LM; Topas Therapeutics GmbH, Hamburg, Germany., Fanzutti M; Topas Therapeutics GmbH, Hamburg, Germany., Vocaturo AL; Topas Therapeutics GmbH, Hamburg, Germany., Mungalpara D; Topas Therapeutics GmbH, Hamburg, Germany., Boyer O; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France; Department of Immunology and Biotherapy, CHU de Rouen, Rouen, France., Lacroix-Desmazes S; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France., Fleischer S; Topas Therapeutics GmbH, Hamburg, Germany. Electronic address: fleischer@topas-therapeutics.com., Adriouch S; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France. Electronic address: sahil.adriouch@univ-rouen.fr.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3854-3871. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.03.009