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Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.

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Title: Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.
Authors: Hardet R; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France., Wang SH; Topas Therapeutics GmbH, Hamburg, Germany., Delignat S; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France., Blandin M; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France., Digigow R; Topas Therapeutics GmbH, Hamburg, Germany., Gottwick C; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Heine M; Department of Biochemistry and Molecular Cell Biology (N30), University Medical Clinic Hamburg-Eppendorf, Hamburg, Germany., Marques Mesquita LM; Topas Therapeutics GmbH, Hamburg, Germany., Fanzutti M; Topas Therapeutics GmbH, Hamburg, Germany., Vocaturo AL; Topas Therapeutics GmbH, Hamburg, Germany., Mungalpara D; Topas Therapeutics GmbH, Hamburg, Germany., Boyer O; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France; Department of Immunology and Biotherapy, CHU de Rouen, Rouen, France., Lacroix-Desmazes S; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France., Fleischer S; Topas Therapeutics GmbH, Hamburg, Germany. Electronic address: fleischer@topas-therapeutics.com., Adriouch S; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France. Electronic address: sahil.adriouch@univ-rouen.fr.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3854-3871. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading.
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  Data: <searchLink fieldCode="AU" term="%22Hardet+R%22">Hardet R</searchLink>; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France.<br /><searchLink fieldCode="AU" term="%22Wang+SH%22">Wang SH</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Delignat+S%22">Delignat S</searchLink>; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France.<br /><searchLink fieldCode="AU" term="%22Blandin+M%22">Blandin M</searchLink>; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France.<br /><searchLink fieldCode="AU" term="%22Digigow+R%22">Digigow R</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gottwick+C%22">Gottwick C</searchLink>; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Heine+M%22">Heine M</searchLink>; Department of Biochemistry and Molecular Cell Biology (N30), University Medical Clinic Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Marques+Mesquita+LM%22">Marques Mesquita LM</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fanzutti+M%22">Fanzutti M</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vocaturo+AL%22">Vocaturo AL</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mungalpara+D%22">Mungalpara D</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boyer+O%22">Boyer O</searchLink>; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France; Department of Immunology and Biotherapy, CHU de Rouen, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Lacroix-Desmazes+S%22">Lacroix-Desmazes S</searchLink>; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, CNRS, Sorbonne Université, Université de Paris, 75006 Paris, France.<br /><searchLink fieldCode="AU" term="%22Fleischer+S%22">Fleischer S</searchLink>; Topas Therapeutics GmbH, Hamburg, Germany. Electronic address: fleischer@topas-therapeutics.com.<br /><searchLink fieldCode="AU" term="%22Adriouch+S%22">Adriouch S</searchLink>; University Rouen Normandie, INSERM, Normandie University, PANTHER, UMR 1234, 76000 Rouen, France. Electronic address: sahil.adriouch@univ-rouen.fr.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3854-3871. <i>Date of Electronic Publication: </i>2026 Mar 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 01
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