PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.
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| Title: | PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen. |
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| Authors: | Salem F; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK. farzaneh.x.salem@gsk.com., Stader F; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Youssef AS; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA., Derbalah A; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Nader A; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA., Hood S; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK., Taskar K; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK. |
| Source: | The AAPS journal [AAPS J] 2026 Mar 13; Vol. 28 (2). Date of Electronic Publication: 2026 Mar 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1550-7416 |
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| DOI: | 10.1208/s12248-026-01228-9 |
