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PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.

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Title: PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.
Authors: Salem F; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK. farzaneh.x.salem@gsk.com., Stader F; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Youssef AS; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA., Derbalah A; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK., Nader A; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA., Hood S; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK., Taskar K; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.
Source: The AAPS journal [AAPS J] 2026 Mar 13; Vol. 28 (2). Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.
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  Data: <searchLink fieldCode="AU" term="%22Salem+F%22">Salem F</searchLink>; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK. farzaneh.x.salem@gsk.com.<br /><searchLink fieldCode="AU" term="%22Stader+F%22">Stader F</searchLink>; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.<br /><searchLink fieldCode="AU" term="%22Youssef+AS%22">Youssef AS</searchLink>; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Derbalah+A%22">Derbalah A</searchLink>; Certara UK Limited, Simcyp Division, Level 2 Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.<br /><searchLink fieldCode="AU" term="%22Nader+A%22">Nader A</searchLink>; Clinical Pharmacology Modeling and Simulation, GSK R&D, Collegeville, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hood+S%22">Hood S</searchLink>; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; Drug Metabolism and Pharmacokinetics, GSK R&D, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 Mar 13; Vol. 28 (2). <i>Date of Electronic Publication: </i>2026 Mar 13.
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      – Type: doi
        Value: 10.1208/s12248-026-01228-9
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        Text: English
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      – TitleFull: PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.
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              Text: 2026 Mar 13
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