Photodynamic priming with Vitamin D and ALA-based PDT induces intratumoral immune cell recruitment and signaling pathway activation in cutaneous squamous cell carcinoma.

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Title: Photodynamic priming with Vitamin D and ALA-based PDT induces intratumoral immune cell recruitment and signaling pathway activation in cutaneous squamous cell carcinoma.
Authors: Shen AS; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA., Anand S; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Biomedical Engineering, Cleveland Clinic Research Institute, Cleveland, OH, USA.; Department of Dermatology, Medical Specialty Institute, Cleveland Clinic, Cleveland, OH, USA., Cheng CE; Department of Biomedical Engineering, Cleveland Clinic Research Institute, Cleveland, OH, USA., Kovacic B; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Powers J; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Diaz-Montero CM; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA., Hasan T; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA., Maytin EV; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA. maytine@ccf.org.; Department of Biomedical Engineering, Cleveland Clinic Research Institute, Cleveland, OH, USA. maytine@ccf.org.; Department of Dermatology, Medical Specialty Institute, Cleveland Clinic, Cleveland, OH, USA. maytine@ccf.org.; Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Mailstop ND-20, Cleveland, OH, 44195, USA. maytine@ccf.org.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Mar 14; Vol. 75 (4). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1432-0851
DOI:10.1007/s00262-026-04347-6