Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

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Title: Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.
Authors: Jiang R; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA., Bogle R; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Xing X; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Kirma J; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Fox J; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Harms PW; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Do T; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Billi AC; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA., Modlin RL; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., Teles R; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., West J; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., Mangold A; Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA., Zhang H; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Schneider MA; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Bruno S; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Roediger B; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Martiny-Baron G; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Hacini-Rachinel F; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Röhn TA; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Mar 14; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-70506-z