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Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.

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Title: Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.
Authors: Jiang R; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA., Bogle R; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Xing X; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Kirma J; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Fox J; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Harms PW; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Do T; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Billi AC; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA., Modlin RL; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., Teles R; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., West J; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA., Mangold A; Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA., Zhang H; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Schneider MA; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Bruno S; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Roediger B; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Martiny-Baron G; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Hacini-Rachinel F; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Röhn TA; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland., Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Mar 14; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell and spatial profiling reveal cDC2A-CXCL13<superscript>+</superscript>CD8<superscript>+</superscript> T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+R%22">Jiang R</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bogle+R%22">Bogle R</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Xing+X%22">Xing X</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kirma+J%22">Kirma J</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fox+J%22">Fox J</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Harms+PW%22">Harms PW</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Do+T%22">Do T</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Billi+AC%22">Billi AC</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kahlenberg+JM%22">Kahlenberg JM</searchLink>; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Modlin+RL%22">Modlin RL</searchLink>; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Teles+R%22">Teles R</searchLink>; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22West+J%22">West J</searchLink>; Department of Dermatology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mangold+A%22">Mangold A</searchLink>; Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+MA%22">Schneider MA</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bruno+S%22">Bruno S</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roediger+B%22">Roediger B</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martiny-Baron+G%22">Martiny-Baron G</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tsoi+LC%22">Tsoi LC</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hacini-Rachinel+F%22">Hacini-Rachinel F</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Röhn+TA%22">Röhn TA</searchLink>; Immunology Disease Area, Novartis BioMedical Research, Novartis Pharma AG, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gudjonsson+JE%22">Gudjonsson JE</searchLink>; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA. johanng@med.umich.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Mar 14; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 14.
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