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Preclinical efficacy and safety assessment of engineered regulatory T cells for treatment of IPEX and other autoimmune disorders.

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Title: Preclinical efficacy and safety assessment of engineered regulatory T cells for treatment of IPEX and other autoimmune disorders.
Authors: Honaker Y; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Dahl NP; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Singh S; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Singh AK; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Lopez C; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Gruber D; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Scharffenberger SC; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Patel S; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Jones H; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Khan IF; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Christian ML; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Yang SJ; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Sommer K; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Torgerson TR; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA., Allenspach EJ; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA., Ito CEK; Casebia Therapeutics, Cambridge, MA 02139, USA., Uenishi GI; Casebia Therapeutics, Cambridge, MA 02139, USA., Cost GJ; Casebia Therapeutics, Cambridge, MA 02139, USA., Cook PJ; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA., Rawlings DJ; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: drawling@uw.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 4035-4053. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Preclinical efficacy and safety assessment of engineered regulatory T cells for treatment of IPEX and other autoimmune disorders.
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  Data: <searchLink fieldCode="AU" term="%22Honaker+Y%22">Honaker Y</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Dahl+NP%22">Dahl NP</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Singh+AK%22">Singh AK</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+C%22">Lopez C</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Gruber+D%22">Gruber D</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Scharffenberger+SC%22">Scharffenberger SC</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Jones+H%22">Jones H</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Khan+IF%22">Khan IF</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Christian+ML%22">Christian ML</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Yang+SJ%22">Yang SJ</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Sommer+K%22">Sommer K</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Torgerson+TR%22">Torgerson TR</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Allenspach+EJ%22">Allenspach EJ</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA.<br /><searchLink fieldCode="AU" term="%22Ito+CEK%22">Ito CEK</searchLink>; Casebia Therapeutics, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Uenishi+GI%22">Uenishi GI</searchLink>; Casebia Therapeutics, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cost+GJ%22">Cost GJ</searchLink>; Casebia Therapeutics, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cook+PJ%22">Cook PJ</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Rawlings+DJ%22">Rawlings DJ</searchLink>; Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: drawling@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 4035-4053. <i>Date of Electronic Publication: </i>2026 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ymthe.2026.03.017
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